Bin Li, Ph.D., Yu He Scholar, Senior Investigator, Unit of Molecular Immunology; Associate Director, Shanghai Institute of Immunology, Distinguished Professor, Shanghai JiaoTong University, Email: binli@shsmu.edu.cn; Cofounder and Chairman of SAB at Biotheus, Inc.
Research Summary: FOXP3 stability and Treg plasticity
Research in my laboratory mainly focuses on understanding molecular mechanism underlying the functional stability, plasticity and balance of FOXP3+ Regulatory T cells (Treg) and RORγt+ T helper 17 cells (Th17) in inflammatory diseases, as well as their therapeutically modulation, especially by compounds from Chinese Traditional Medicine. By using and developing Treg specifically depletion of key enzymatic subunits of FOXP3 complex animal models, as well as these state-of-art cutting-edge technologies in single cell sequencing and immune cell metabolism, we are revealing the functional role of peripheral tissue-specific Treg cells in vitro and in vivo in health and disease settings. We expect that our original findings will be translational to biomedical industry and be beneficial to human health.
Lab Web page:
http://sii.shsmu.edu.cn/En/DetailMemberInfo2.php?pid = 5&cid = 31&num = 31&id = 70
Google Scholar Citation :
https://scholar.google.com/citations?user = 7eRUHTIAAAAJ&hl = en
(H-index:33 ; i10-index: 67)
Education & Professional Experience
2016 -now Yu He Scholar, Distinguished Professor and Associate Director of Shanghai Institute of Immunology, Shanghai Jiao Tong University
2009-2016 Professor, Principal Investigator, Institut Pasteur of Shanghai, Chinese Academy of Sciences
2006-2009 Faculty Research associate, University of Pennsylvania School of Medicine
2002-2003 Visiting Research Scholar, Sir William Dunn School of Pathology, Oxford University
2001-2006 Postdoctoral Fellow, University of Pennsylvania School of Medicine
1996-2001 Peking University College of Life Sciences, Ph.D.;
1992-1996 Anhui Normal University, Diploma in Biology;
Awards and Scientific Community Services
2018 The second prize scholarship for National Prize for Progress in Science and Technology
2016 Ye He Scholar, Shanghai Institute of Immunology
2016 Shanghai Subject Chief Scientist, Shanghai
2015 Distinguished Young Scholars, NSFC
2010 100-talent program of CAS
2010 Shanghai Rising-Star Program for Young Scientists
2018, 2019 Peer Reviewer for MRC (UK)
2019 Peer Reviewr for NCN (Poland)
Since 2018 Associate Editor of Science Bulletin
Since 2008 Guest Editorial board member of Engineering
Since 2016 Editorial board member of Cellular and Molecular Immunology
Since 2019 Associate Editor, the Editorial Board of Cell Death and Survival, a specialty section within Frontiers in Cell and Developmental Biology
Since 2020 ExCo member, Associate Editor of European Journal of Immunology
Publications in 2020 (* co-corresponding authors)
1. Hao Cheng, Lingbiao Wang, Biaolong Yang, Dan Li, Xiaoxia Wang, Xinnan Liu, Na Tian, Qianru Huang, Ru Feng, Zhengting Wang, Rui Liang, Sheng-Ming Dai, Ling Lv, Ji Wu*, Yuan-Sheng Zang*, and Bin Li*. Cutting Edge: Inhibition of Glycogen Synthase Kinase 3 Activity Induces the Generation and Enhanced Suppressive Function of Human IL-10+FOXP3+–Induced Regulatory T Cells. Journal of Immunology, 2020. in press. (205:000-000,www.jimmunol.org/cgi/doi/10.4049/jimmunol.2000136)
2. Jing Yang, Ping Wei, Joseph Barbi, Qianru Huang, Evan Yang, Yakun Bai, Jia Nie, Yanhang Gao, Jinhui Tao, Ying Lu, Chichu Xie, Xiaoxia Hou, Jiazi Ren, Xingmei Wu, Jian Meng, Ying Zhang, Juan Fu, Wei Kou, Yayi Gao, Zuojia Chen, Rui Liang, Andy Tsun, Dan Li, Wenzhi Guo, Shuijun Zhang, Song‐Guo Zheng, Junqi Niu, Paul Galardy, Xuemei Tong, Guochao Shi, Huabin Li*, Fan Pan*, Bin Li*. The deubiquitinase USP44 promotes Treg function during inflammation by preventing FOXP3 degradation. EMBO Reports, 2020,. [Link]
3. Aiting Wang, Mengdi Yang, Rui Liang, Fangming Zhu, Fuxiang Zhu, Xinnan Liu, Yichao Han, Ruirong Lin, Xiaoxia Wang, Dan Li, Hecheng Li, Xiaojun Yuan, Hui Zhao*, Bin Li*. Mouse Double Minute 2 Homolog-Mediated Ubiquitination Facilitates Forkhead Box P3 Stability and Positively Modulates Human Regulatory T Cell Function. Frontiers in Immunology, 2020,. [Link]
4. Bai F, Zhang P, Fu Y, Chen H, Zhang M, Huang Q, Li D*, Li B*, Wu K*. Targeting ANXA1 abrogates Treg-mediated immune suppression in triple-negative breast cancer. J Immunother Cancer. 2020 Apr;8(1):e000169. doi: 10.1136/jitc-2019-000169.
5. Mengdi Yang, Aiting Wang, Changcan Li, Jing Sun, Gang Yi, Cheng Hao, Xueni Liu, Zhiyu Wang, Yiyi Zhou, Guangyu Yao, Shuai Wang, Rui Liang, Bin Li*, Dan Li*, Hui Zhao*. Methylation-induced silencing of ALDH2 facilitates lung adenocarcinoma bone metastasis by activating the MAPK pathway. Frontiers in Oncology, 2020,. [Link]
6. Gang Yi, Yi Zhao, Feng Xie, Fuxiang Zhu, Ziyun Wan, Xiu Qiu, Huanming Yang, Jian Wang, Bing Su, Lei Chen, Wei Zhang, Yong Hou, Xun Xu, Yinyan He, Andy Tsun, Xiao Liu*, Bin Li*.. Single-cell RNA-seq unveils critical regulators of human FOXP3+ regulatory T cell stability. Science Bulletin, 2020,. [Link]
7. Zhao J, Zhang Y, Liu XS, Zhu FM, Xie F, Jiang CY, Zhang ZY, Gao YL, Wang YC, Li B*, Xia SJ*, Han BM*..NA‐binding protein Musashi2 stabilizing androgen receptor drives prostate cancer progression. Cancer Sci.,2020,. [Link]
8. Qianru Huang, Xu Liu, Yujia Zhang, Jingyao Huang, Dan Li*, Bin Li*..Molecular feature and therapeutic perspectives of immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome. Journal of Genetics and Genomics, 2020,. [Link]
9. Huang J, Wang S, Jia Y, Zhang Y, Dai X*, Li B*. Targeting FOXP3 complex ensemble in drug discovery. Adv Protein Chem Struct Biol. 2020;121:143-168. doi: 10.1016/bs.apcsb.2019.11.010. Epub 2020 Jan 7.
Complete Publication list :
https://scholar.google.com/citations?hl = en&user = 7eRUHTIAAAAJ&view_op = list_works&sortby = pubdate